Oral lichen planus (OLP) is a relatively common, chronic inflammatory disease that often affects the stratified squamous epithelia of oral mucosa. The disease is affecting approximately 1-2% of the population. It is seen mostly in the third to sixth decades of life, and is twice as common in women than men. OLP's pathogenesis of immune system is thought to have played a role in the etiology is not known. A 25-year-old male patient was referred our clinic due to white lesions on his lower lip. Similar lesions were detected on his tongue, retromolar region, gingiva as well as various parts of oral mucosa result of clinical examiation. Biopsies were taken for direct immunofluorescense (DIF) and histopathological examinations. As a result of bipsies OLP were diagnosed. In this paper the treatment of our patient and the clinical changes of patient with the treatment will be presented.