Investigation of carbamazepine (CBP) extraction by four solvent systems containing ionic liquids (1-Butyl-3-methylimidazolium tetrafluoroborate-IL-1 and 1-Butyl-3-methyl-imidazolium hexafluoro phosphate-IL-2) as extractant in four diluents (diethyl adipate-DEA, diethyl malonate-DEM, diethyl succinate-DES and dibutyl phthalate-DBP) was performed at ambient temperature. The results were evaluated in terms of extraction yield (%) and distribution coefficient. IL-2 + DEA extractant system had the highest yield of CBP recovery with 88.45%. Regarding IL-1, the best performance was achieved by DEM with 82.03% of CBP recovery. Neutral media with the lowest addition of ionic liquid (20%, v/v) was found to be the optimum conditions to obtain the maximum recovery. (C) 2018 Elsevier B.V. All rights reserved.