Current Status of the Use of Single-Nucleotide Polymorphisms in Forensic Practices

CANTURK K. M., Emre R., KINOGLU K., BASPINAR B., SAHIN F., Ozen M.

GENETIC TESTING AND MOLECULAR BIOMARKERS, cilt.18, sa.7, ss.455-460, 2014 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 18 Sayı: 7
  • Basım Tarihi: 2014
  • Doi Numarası: 10.1089/gtmb.2013.0466
  • Dergi Adı: GENETIC TESTING AND MOLECULAR BIOMARKERS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.455-460
  • İstanbul Üniversitesi Adresli: Hayır

Özet

Forensic geneticists often use short tandem repeats (STRs) to solve cases. However, STRs can be insufficient when DNA samples are degraded due to environmental exposure and mass disasters, alleged and real relatives are genetically related in paternity or kinship analyses, or a suspect is lacking. In such cases, single-nucleotide polymorphisms (SNPs) can provide valuable information and thus should be seriously considered as a tool to help resolve challenging cases. In this review, the current status of SNP analyses in forensic applications and the comparative advantages and disadvantages of SNPs with other biomarkers are discussed.