Soluble urokinase plasminogen activator receptor (suPAR) levels predict damage accrual in patients with recent-onset systemic lupus erythematosus

Enocsson, Helena; Wirestam, Lina; Dahle, Charlotte; Padyukov, Leonid; Jonsen, Andreas; Urowitz, Murray; Gladmane, Dafna; ROMERO-DIAZ, Juanita; BAE, Sang-Cheol; Fortin, Paul; Sanchez-Guerrero, Jorge; Clarke, Ann; Bernatsky, Sasha; Gordon, Caroline; HANLY, John; WALLACE, Daniel; Isenberg, David; Rahman, Anisur; MERRILL, Joan; GINZLER, Ellen; ALARCON, Graciela; CHATHAM, W.; Petri, Michelle; KHAMASHTA, Munther; ARANOW, Cynthia; MACKAY, Meggan; Dooley, Mary; MANZI, Susan; Ramsey-Goldman, Rosalind; Nived, Ola; STEINSSON, Kristjan; ZOMA, Asad; RUIZ-IRASTORZA, Guillermo; Lim, S.; KALUNIAN, Kenneth; Inanc, Murat; VAN VOLLENHOVEN, Ronald; RAMOS-CASALS, Manuel; KAMEN, Diane; JACOBSEN, Soren; Peschken, Christine; Askanase, Anca; STOLL, Thomas; Bruce, Ian; Wettero, Jonas; Sjowall, Christopher

doi:10.1016/j.jaut.2019.102340

Soluble urokinase plasminogen activator receptor (suPAR) levels predict damage accrual in patients with recent-onset systemic lupus erythematosus

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Enocsson H., Wirestam L., Dahle C., Padyukov L., Jonsen A., Urowitz M. B., ...More

JOURNAL OF AUTOIMMUNITY, vol.106, 2020 (SCI-Expanded)

Publication Type: Article / Article
Volume: 106
Publication Date: 2020
Doi Number: 10.1016/j.jaut.2019.102340
Journal Name: JOURNAL OF AUTOIMMUNITY
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, PASCAL, BIOSIS, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database
Keywords: Biomarker, SLE, Organ damage, Prognosis, Outcome, C-REACTIVE PROTEIN, ORGAN DAMAGE, INTERFERON-ALPHA, DISEASE-ACTIVITY, INDEX, EFFEROCYTOSIS, BINDING, POPULATION, MORTALITY, SEVERITY
Istanbul University Affiliated: Yes

Abstract

Objective: The soluble urokinase plasminogen activator receptor (suPAR) has potential as a prognosis and severity biomarker in several inflammatory and infectious diseases. In a previous cross-sectional study, suPAR levels were shown to reflect damage accrual in cases of systemic lupus erythematosus (SLE). Herein, we evaluated suPAR as a predictor of future organ damage in recent-onset SLE.