Soluble urokinase plasminogen activator receptor (suPAR) levels predict damage accrual in patients with recent-onset systemic lupus erythematosus


Enocsson H., Wirestam L., Dahle C., Padyukov L., Jonsen A., Urowitz M. B., ...More

JOURNAL OF AUTOIMMUNITY, vol.106, 2020 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 106
  • Publication Date: 2020
  • Doi Number: 10.1016/j.jaut.2019.102340
  • Journal Name: JOURNAL OF AUTOIMMUNITY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, PASCAL, BIOSIS, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database
  • Keywords: Biomarker, SLE, Organ damage, Prognosis, Outcome, C-REACTIVE PROTEIN, ORGAN DAMAGE, INTERFERON-ALPHA, DISEASE-ACTIVITY, INDEX, EFFEROCYTOSIS, BINDING, POPULATION, MORTALITY, SEVERITY
  • Istanbul University Affiliated: Yes

Abstract

Objective: The soluble urokinase plasminogen activator receptor (suPAR) has potential as a prognosis and severity biomarker in several inflammatory and infectious diseases. In a previous cross-sectional study, suPAR levels were shown to reflect damage accrual in cases of systemic lupus erythematosus (SLE). Herein, we evaluated suPAR as a predictor of future organ damage in recent-onset SLE.