A reversed-phase high-performance liquid chromatographic (HPLC) method with UV detection was developed and validated for the determination of ropinirole (ROP) in tablets. The assay utilized UV detection at 250 nm and a Luna CN column (250 x 4.6 mm I.D, 5 mu m). The mobile phases were comprised of acetonitrile: 10 mM nitric acid (pH 3.0) (75:25, v/v). Validation experiments were performed to demonstrate linearity, accuracy, precision, limit of quantitation (LOQ), limit of detection (LOD), and robustness. The method was linear over the concentration range of 0.5-10.0 mu g mL(-1). The method showed good recoveries (99.75-100.20%) and the relative standard deviations of intra and inter-day assays were 0.38-1.69 and 0.45-1.95%, respectively. The method can be used for quality control assay of ropinirole.