Waning effectiveness of CoronaVac in real life: A retrospective cohort study in health care workers


CAN G., ACAR H. C., Aydin S. N., BALKAN İ. İ., KARAALİ R., BUDAK B., ...Daha Fazla

VACCINE, cilt.40, sa.18, ss.2574-2579, 2022 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 40 Sayı: 18
  • Basım Tarihi: 2022
  • Doi Numarası: 10.1016/j.vaccine.2022.03.032
  • Dergi Adı: VACCINE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, PASCAL, BIOSIS, Biotechnology Research Abstracts, CAB Abstracts, EMBASE, Environment Index, MEDLINE, Public Affairs Index, Veterinary Science Database
  • Sayfa Sayıları: ss.2574-2579
  • Anahtar Kelimeler: Inactivated vaccine, COVID-19 vaccine, Health care workers, Vaccine effectiveness
  • İstanbul Üniversitesi Adresli: Hayır

Özet

Background: Real-world studies showed varying levels of effectiveness of CoronaVac vaccine against COVID-19 disease. This study aimed to assess the association between the vaccination with CoronaVac and the COVID-19 infections among the health care workers in a university hospital and to determine the vaccine effectiveness against COVID-19 in a period when alpha variant was dominant.Methods: This retrospective cohort study was conducted in a university hospital in Istanbul, Turkey employs 4067 health care workers. The follow-up period was defined as starting 14 days after receiving the second dose for fully vaccinated group. Health care workers were censored when have a positive PCR test result or at the end of the study. Unvaccinated health care workers were censored if they receive any COVID-19 vaccine doses. The incidence rate ratio and Cox regression were used to estimate the unadjusted and adjusted effectiveness of the vaccine.