Increased expression of exon 2 deleted MEFV transcript in familial Mediterranean fever patients


Kirectepe A. K. , Erdem G. C. , Senturk N., Arisoy N., Hatemi G., Ozdogan H., ...Daha Fazla

INTERNATIONAL JOURNAL OF IMMUNOGENETICS, cilt.38, sa.4, ss.327-329, 2011 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 38 Konu: 4
  • Basım Tarihi: 2011
  • Doi Numarası: 10.1111/j.1744-313x.2011.01015.x
  • Dergi Adı: INTERNATIONAL JOURNAL OF IMMUNOGENETICS
  • Sayfa Sayıları: ss.327-329

Özet

A defect in MEFV gene expression regulation has been implicated in familial Mediterranean fever (FMF) etiopathophysiology. Here we show significantly higher expression level in second exon lacking MEFV transcript in FMF patients compared with healthy controls (P = 0.026). Our results also point out a possible role of exon 2 deleted MEFV transcript in FMF pathogenesis.