Polymorphisms of the DNA Repair Genes XPD and XRCC1 and the Risk of Age-Related Macular Degeneration
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, cilt.51, sa.9, ss.4732-4737, 2010 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 51 Sayı: 9
- Basım Tarihi: 2010
- Doi Numarası: 10.1167/iovs.09-4842
- Dergi Adı: INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.4732-4737
- İstanbul Üniversitesi Adresli: Evet
Özet
PURPOSE. Oxidative stress seems to be an important factor in the development of age-related macular degeneration (AMD). The role of DNA repair mechanisms has also received attention recently in AMD pathogenesis. This case-control study was conducted to determine the frequency of polymorphisms in two DNA repair enzyme genes, xeroderma pigmentosum complementation group D (XPD), codons 312 and 751, and x-ray cross-complementing group 1 (XRCC1), codons 194 and 399, in patients with AMD and in disease-free control subjects.