Experimentally induced puromycine aminonucleoside nephrosis (PAN) in rats: evaluation of angiogenic protein platelet-derived endothelial cell growth factor (PD-ECGF) expression in glomeruli.

Seckin I., Uzunalan M., Pekpak M., Kokturk S., Sonmez H. A., Ozturk Z., ...Daha Fazla

Journal of biomedical science, cilt.19, ss.24, 2012 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 19
  • Basım Tarihi: 2012
  • Doi Numarası: 10.1186/1423-0127-19-24
  • Dergi Adı: Journal of biomedical science
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.24
  • Anahtar Kelimeler: puromycine aminonucleoside nephritis, PD-ECGF, angiogenesis, macrophage, ultrastructure, rat, BLOOD-VESSEL FORMATION, THYMIDINE PHOSPHORYLASE, LUMEN FORMATION, FACTOR/THYMIDINE PHOSPHORYLASE, PODOCYTE, ALPHA(5)BETA(1), ALPHA(V)BETA(3), VASCULOGENESIS, RECEPTORS, INTEGRINS
  • İstanbul Üniversitesi Adresli: Evet

Özet

Background: In experimentally induced puromycine aminonucleoside nephrosis (PAN) animal models, nephrotic syndrome with minimal change disease and focal and segmental sclerosis-like nephritis similar to that in human is demonstrated; however, the real mechanism of PAN is not yet elucidated. Platelet derived endothelial cell growth factor (PD-ECGF), an endothelial mitogen protein, is believed to take part in microvessel formation and in stimulation of angiogenesis and its expression has not been totally demonstrated in PAN rats yet. In this study, we aimed to examine PD-ECGF expression in acute and chronic PAN induced in rats and find out the association between its expression and the stages of angiogenesis in kidney.