TGF-β1 neutralizing antibodies decrease the fibrotic effects of ischemic priapism

Sanli O., Armagan A., Kandirali E., Ozerman B. , Ahmedov I., Solakoglu S., ...Daha Fazla

International Journal of Impotence Research, cilt.16, sa.6, ss.492-497, 2004 (SCI Expanded İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 16 Konu: 6
  • Basım Tarihi: 2004
  • Doi Numarası: 10.1038/sj.ijir.3901261
  • Dergi Adı: International Journal of Impotence Research
  • Sayfa Sayıları: ss.492-497


The objective of this study was to evaluate the possible role of transforming growth factor beta 1 (TGF-β1) antibodies (ab) for the prevention of fibrotic effects of priapism in a rat model. In total, 30 adult Sprague-Dawley rats were divided into five groups. Priapism with 6 h (group 1), priapism with 6 h + ab (group 2), priapism with 24 h (group 3), priapism with 24 h + ab (group 4) and control (group 5). Priapism was induced with a vacuum erection device and a rubber band was placed at the base of the erect penis. At 1 h after the initiation of priapism, TGF-β1 antibodies were given intracavernosaly. All rats underwent electrical stimulation of the cavernous nerve after 8 weeks. Intracavernous and systemic blood pressures were measured during the procedure. Rats in group 1 showed significantly higher (intracavemosal pressure (ICP) pressures to cavernous nerve stimulation and had higher ICP/BP ratios when compared to other groups. Similarly, histopathologic examination revealed less fibrosis in group 2, compared with the other groups. Consequently, TGF-β1 antibodies antagonise the fibrotic effects of TGF-β1, especially in cases with duration of priapism less than 6 h.