Therapeutic vaccination in chronic hepatitis B


Senturk H., Tabak F. , Akdogan M., Erdem L., Mert A., Ozaras R. , et al.

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, cilt.17, ss.72-76, 2002 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 17 Konu: 1
  • Basım Tarihi: 2002
  • Doi Numarası: 10.1046/j.1440-1746.2002.02652.x
  • Dergi Adı: JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
  • Sayfa Sayısı: ss.72-76

Özet

Aims: The aim was to test the efficacy of a pre-S2-containing vaccine (Genhevac-B) in chronic hepatitis B (CHB). Twenty-five naive patients (22 male, three female; median age 35; range: 6-69 years) with CHB were recruited. The inclusion criteria were: hepatitis B e antigen (HBeAg) positive or HBV-DNA detectable with liquid hybridization; alanine aminotransferase (ALT) is at least 1.5-fold the upper normal limit and histological evidence of chronic hepatitis.