Efficacy of interferon alpha-2b and lamivudine combination treatment in comparison to interferon alpha-2b alone in chronic delta hepatitis: A randomized trial

Canbakan, B; Senturk, H; Tabak, Ömer; Akdogan, M; Tahan, V; Mert, A; Sut, Necdet; Ozaras, Reşat; Midilli, Kenan; Ozbay, Gülşen

doi:10.1111/j.1440-1746.2006.04082.x

Efficacy of interferon alpha-2b and lamivudine combination treatment in comparison to interferon alpha-2b alone in chronic delta hepatitis: A randomized trial

Atıf İçin Kopyala

Canbakan B., Senturk H., Tabak F., Akdogan M., Tahan V., Mert A., ...Daha Fazla

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, cilt.21, sa.4, ss.657-663, 2006 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 21 Sayı: 4
Basım Tarihi: 2006
Doi Numarası: 10.1111/j.1440-1746.2006.04082.x
Dergi Adı: JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.657-663
İstanbul Üniversitesi Adresli: Evet

Özet

Background and Aim: Delta hepatitis is characterized by rapidly progressive liver disease with adverse prognosis in most patients. Patients benefit from high doses and prolonged courses of interferon (IFN) therapy; however, lamivudine as a single agent has been disappointing. Data relating to the efficacy of IFN and lamivudine in combination is limited. The aim of this study was to test the efficacy of IFN-alpha 2b and lamivudine combination treatment in comparison to IFN-alpha 2b alone in patients with chronic delta hepatitis.