Pharmacokinetics and pharmacodynamics of aprepitant for the prevention of postoperative nausea and vomiting in pediatric subjects

Salman F. T., DiCristina C., Chain A., Afzal A. S.

JOURNAL OF PEDIATRIC SURGERY, cilt.54, sa.7, ss.1384-1390, 2019 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 54 Sayı: 7
  • Basım Tarihi: 2019
  • Doi Numarası: 10.1016/j.jpedsurg.2018.09.006
  • Dergi Adı: JOURNAL OF PEDIATRIC SURGERY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1384-1390
  • İstanbul Üniversitesi Adresli: Evet

Özet

Background/purpose: This multicenter, randomized, partially-blinded phase IIb study evaluated the pharmacokinetics (PK)/pharmacodynamics, safety, and tolerability of aprepitant in pediatric subjects for the prevention of postoperative nausea and vomiting (PONV).