Loss of heterozygosity at chromosome 14q is associated with poor prognosis in head and neck squamous cell carcinomas

Pehlivan, Davut; Gunduz, Esra; Gunduz, Mehmet; Nagatsuka, Hitoshi; Beder, Levent; Cengiz, Beyhan; Rivera, Rosario; Fukushima, Kunihiro; Palanduz, Şükrü; Ozturk, Şükrü; Yamanaka, Noboru; Shimizu, Kenji

doi:10.1007/s00432-008-0423-1

Loss of heterozygosity at chromosome 14q is associated with poor prognosis in head and neck squamous cell carcinomas

Atıf İçin Kopyala

Pehlivan D., Gunduz E., Gunduz M., Nagatsuka H., Beder L. B., Cengiz B., ...Daha Fazla

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, cilt.134, sa.12, ss.1267-1276, 2008 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 134 Sayı: 12
Basım Tarihi: 2008
Doi Numarası: 10.1007/s00432-008-0423-1
Dergi Adı: JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.1267-1276
Anahtar Kelimeler: Head and neck squamous cell carcinoma, Loss of heterozygosity, 14q, Microsatellite marker, Survival, D14S995, D14S67, TYROSINE-PHOSPHATASE D1, TUMOR-SUPPRESSOR GENE, ALLELIC LOSS, CANCER STATISTICS, DELETION, PROTEIN, REGULATOR, 13Q
İstanbul Üniversitesi Adresli: Evet

Özet

Purpose and methods Loss of heterozygosity (LOH) in a chromosomal location indicates the presence of an inactivated tumor suppressor gene (TSG). Inactivation of TSG has a functional role in the tumorigenesis of head and neck squamous cell carcinoma (HNSCC). Based on the recent evidences of a putative TSG on chromosome 14, we examined LOH on chromosome 14q using eight polymorphic microsatellite markers in 50 cases of HNSCCs.