Loss of heterozygosity at chromosome 14q is associated with poor prognosis in head and neck squamous cell carcinomas


Pehlivan D., Gunduz E., Gunduz M., Nagatsuka H., Beder L. B. , Cengiz B., ...More

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, vol.134, no.12, pp.1267-1276, 2008 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 134 Issue: 12
  • Publication Date: 2008
  • Doi Number: 10.1007/s00432-008-0423-1
  • Journal Name: JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1267-1276
  • Keywords: Head and neck squamous cell carcinoma, Loss of heterozygosity, 14q, Microsatellite marker, Survival, D14S995, D14S67, TYROSINE-PHOSPHATASE D1, TUMOR-SUPPRESSOR GENE, ALLELIC LOSS, CANCER STATISTICS, DELETION, PROTEIN, REGULATOR, 13Q
  • Istanbul University Affiliated: Yes

Abstract

Purpose and methods Loss of heterozygosity (LOH) in a chromosomal location indicates the presence of an inactivated tumor suppressor gene (TSG). Inactivation of TSG has a functional role in the tumorigenesis of head and neck squamous cell carcinoma (HNSCC). Based on the recent evidences of a putative TSG on chromosome 14, we examined LOH on chromosome 14q using eight polymorphic microsatellite markers in 50 cases of HNSCCs.