Loss of heterozygosity at chromosome 14q is associated with poor prognosis in head and neck squamous cell carcinomas


Pehlivan D., Gunduz E., Gunduz M., Nagatsuka H., Beder L. B., Cengiz B., ...More

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, vol.134, no.12, pp.1267-1276, 2008 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 134 Issue: 12
  • Publication Date: 2008
  • Doi Number: 10.1007/s00432-008-0423-1
  • Journal Name: JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1267-1276
  • Keywords: Head and neck squamous cell carcinoma, Loss of heterozygosity, 14q, Microsatellite marker, Survival, D14S995, D14S67, TYROSINE-PHOSPHATASE D1, TUMOR-SUPPRESSOR GENE, ALLELIC LOSS, CANCER STATISTICS, DELETION, PROTEIN, REGULATOR, 13Q
  • Istanbul University Affiliated: Yes

Abstract

Purpose and methods Loss of heterozygosity (LOH) in a chromosomal location indicates the presence of an inactivated tumor suppressor gene (TSG). Inactivation of TSG has a functional role in the tumorigenesis of head and neck squamous cell carcinoma (HNSCC). Based on the recent evidences of a putative TSG on chromosome 14, we examined LOH on chromosome 14q using eight polymorphic microsatellite markers in 50 cases of HNSCCs.