Loss of heterozygosity at chromosome 14q is associated with poor prognosis in head and neck squamous cell carcinomas


Pehlivan D., Gunduz E., Gunduz M., Nagatsuka H., Beder L. B. , Cengiz B., ...Daha Fazla

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, cilt.134, ss.1267-1276, 2008 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 134 Konu: 12
  • Basım Tarihi: 2008
  • Doi Numarası: 10.1007/s00432-008-0423-1
  • Dergi Adı: JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
  • Sayfa Sayıları: ss.1267-1276

Özet

Purpose and methods Loss of heterozygosity (LOH) in a chromosomal location indicates the presence of an inactivated tumor suppressor gene (TSG). Inactivation of TSG has a functional role in the tumorigenesis of head and neck squamous cell carcinoma (HNSCC). Based on the recent evidences of a putative TSG on chromosome 14, we examined LOH on chromosome 14q using eight polymorphic microsatellite markers in 50 cases of HNSCCs.