Effects of boric acid on cell death and oxidative stress of mouse TM3 Leydig cells in vitro

YALÇIN C. Ö., Abudayyak M. F.

JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY, vol.61, 2020 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 61
  • Publication Date: 2020
  • Doi Number: 10.1016/j.jtemb.2020.126506
  • Journal Name: JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, CAB Abstracts, EMBASE, Food Science & Technology Abstracts, MEDLINE, Veterinary Science Database
  • Keywords: Boric acid, TM3 mouse Leydig cells, Apoptosis, Oxidative stress, DEVELOPMENTAL TOXICITY, BORON-COMPOUNDS, EXPOSURE, GROWTH, ASSAY, MICE, BA
  • Istanbul University Affiliated: Yes

Abstract

Background: Boron (B) is an abundant element on earth and presents at physiological pH in the form of boric acid (BA). It has both positive and negative effects on biological systems. BA and sodium borates have been considered as being toxic to the reproduction system in animal experiments. Unfortunately, the molecular mechanism underlying the toxic effects of BA is not fully understood.