Effects of boric acid on cell death and oxidative stress of mouse TM3 Leydig cells in vitro

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YALÇIN C. Ö., Abudayyak M. F.

JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY, cilt.61, 2020 (SCI-Expanded)

• Yayın Türü: Makale / Tam Makale
• Cilt numarası: 61
• Basım Tarihi: 2020
• Doi Numarası: 10.1016/j.jtemb.2020.126506
• Dergi Adı: JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
• Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, CAB Abstracts, EMBASE, Food Science & Technology Abstracts, MEDLINE, Veterinary Science Database
• Anahtar Kelimeler: Boric acid, TM3 mouse Leydig cells, Apoptosis, Oxidative stress, DEVELOPMENTAL TOXICITY, BORON-COMPOUNDS, EXPOSURE, GROWTH, ASSAY, MICE, BA
• İstanbul Üniversitesi Adresli: Evet

Özet

Background: Boron (B) is an abundant element on earth and presents at physiological pH in the form of boric acid (BA). It has both positive and negative effects on biological systems. BA and sodium borates have been considered as being toxic to the reproduction system in animal experiments. Unfortunately, the molecular mechanism underlying the toxic effects of BA is not fully understood.