Joint immobilization increases reactive oxygen species: an experimental study


Erdem M., GÜNEŞ T., ŞEN C. , Bostan B., Aslan H., Ozyurt H., ...More

ACTA ORTHOPAEDICA ET TRAUMATOLOGICA TURCICA, vol.43, no.5, pp.436-443, 2009 (Peer-Reviewed Journal) identifier

  • Publication Type: Article / Article
  • Volume: 43 Issue: 5
  • Publication Date: 2009
  • Doi Number: 10.3944/aott.2009.436
  • Journal Name: ACTA ORTHOPAEDICA ET TRAUMATOLOGICA TURCICA
  • Journal Indexes: Science Citation Index Expanded, Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.436-443
  • Keywords: Antioxidants, cartilage, articular/pathology, immobilization, knee joint, osteoarthritis, oxidative stress, rabbits, reactive oxygen species, tibia/pathology, time factors, ARTICULAR-CARTILAGE, SUPEROXIDE-DISMUTASE, LIPID-PEROXIDATION, KNEE-JOINT, OSTEOARTHRITIS, REMOBILIZATION, DEGRADATION, RADICALS, FLUID

Abstract

Objectives: It has been shown that reactive oxygen species (ROS) contribute to the onset and progression of osteoarthritis. We investigated cartilage destruction and oxidative stress parameters in the blood and synovial fluid of knee joints of rabbits exposed to varying periods of immobilization.