Predictors of treatment requirement in HBeAg-negative chronic hepatitis B patients with persistently normal alanine aminotransferase and high serum HBV DNA levels

Ormeci A., Aydın Y., Sumnu A. , Baran B. , Soyer O. M. , Pinarbasi B., ...More

International Journal of Infectious Diseases, vol.52, pp.68-73, 2016 (Journal Indexed in SCI Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 52
  • Publication Date: 2016
  • Doi Number: 10.1016/j.ijid.2016.09.007
  • Title of Journal : International Journal of Infectious Diseases
  • Page Numbers: pp.68-73


Objectives: Serum alanine aminotransferase (ALT) is a controversial marker for disease monitoring in hepatitis B e antigen (HBeAg)-negative chronic hepatitis B (CHB) patients. The aim of this study was to determine the fibrosis stage and histological activity index (HAI) in HBeAg-negative CHB patients with persistently normal ALT (PNALT) and high serum HBV DNA (>= 2000 IU/ml) and to investigate clinical risk factors for the requirement of treatment through the examination of liver biopsy specimens.