Predictors of treatment requirement in HBeAg-negative chronic hepatitis B patients with persistently normal alanine aminotransferase and high serum HBV DNA levels


Ormeci A., Aydın Y., Sumnu A., Baran B., Soyer O. M., Pinarbasi B., ...More

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES, vol.52, pp.68-73, 2016 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 52
  • Publication Date: 2016
  • Doi Number: 10.1016/j.ijid.2016.09.007
  • Journal Name: INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.68-73
  • Keywords: Chronic hepatitis B, HBeAg-negative, Persistently normal ALT, NORMAL ALT, NATURAL-HISTORY, VIRUS INFECTION, GUIDELINES, MANAGEMENT, SEROCONVERSION, RISK
  • Istanbul University Affiliated: Yes

Abstract

Objectives: Serum alanine aminotransferase (ALT) is a controversial marker for disease monitoring in hepatitis B e antigen (HBeAg)-negative chronic hepatitis B (CHB) patients. The aim of this study was to determine the fibrosis stage and histological activity index (HAI) in HBeAg-negative CHB patients with persistently normal ALT (PNALT) and high serum HBV DNA (>= 2000 IU/ml) and to investigate clinical risk factors for the requirement of treatment through the examination of liver biopsy specimens.