Induction of long-term glycemic control in newly diagnosed type 2 diabetic patients by transient intensive insulin treatment

Ilkova H., Glaser B., Tunckale A., Bagriacik N., Cerasi E.

DIABETES CARE, cilt.20, ss.1353-1356, 1997 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 20 Konu: 9
  • Basım Tarihi: 1997
  • Doi Numarası: 10.2337/diacare.20.9.1353
  • Dergi Adı: DIABETES CARE
  • Sayfa Sayıları: ss.1353-1356


OBJECTIVE - Type 2 diabetes is a slowly progressive disease, in which the gradual deterioration of glucose tolerance is associated with the progressive decrease in beta-cell function. Hyperglycemia per se has deleterious effects on both beta-cell function and insulin action, which are partially reversible by the short-term control of blood glucose levels. We hypothesized that the induction of euglycemia, using intensive insulin therapy at the time of clinical diagnosis, could lead to a significant improvement in insulin secretion and action and thus alter the clinical course of the disease.