Association between MTHFR C677T polymorphism and folate, vitamin B12, homocysteine, and DNA fragmentation in patients with ovarian cancer
TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI, vol.41, no.6, pp.459-465, 2016 (SCI-Expanded, Scopus, TRDizin)
- Publication Type: Article / Article
- Volume: 41 Issue: 6
- Publication Date: 2016
- Doi Number: 10.1515/tjb-2016-0151
- Journal Name: TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
- Page Numbers: pp.459-465
- Istanbul University Affiliated: Yes
Abstract
Objective: Methylenetetrahydrofolate reductase (MTHFR) is an important enzyme that regulates the metabolism of methionine and folate. MTHFR C677T polymorphism was reported to be associated with breast and ovarian cancer. The aim of this study was to evaluate the association between the MTHFR C677T (rs1801133) polymorphism and homocysteine, vitamin B-12, and folate levels, and DNA fragmentation in patients with ovarian cancer and healthy controls.