Short-Term Results of Ivabradine versus Metoprolol: The Effects on Atrial Fibrillation in Patients Undergoing Off-Pump Coronary Artery Bypass Grafting

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Tekin E. E., Yesiltas M. A., Haberal I.

BRAZILIAN JOURNAL OF CARDIOVASCULAR SURGERY, vol.37, no.6, pp.857-865, 2022 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 37 Issue: 6
  • Publication Date: 2022
  • Doi Number: 10.21470/1678-9741-2021-0201
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE, Directory of Open Access Journals
  • Page Numbers: pp.857-865
  • Keywords: Ivabradine, Metoprolol, Beta-Blocker, Atrial Fibrillation, Coronary Artery Bypass, Erythrocyte Transfusion, Ventricular Fibrilation, Follow-Up Studies, HEART-FAILURE ASSOCIATION, BETA-BLOCKERS, TASK-FORCE, EUROPEAN-SOCIETY, GUIDELINES, SURGERY, ESC, COLLABORATION, DYSFUNCTION, MANAGEMENT
  • Istanbul University Affiliated: Yes


Introduction: Classic coronary artery bypass grafting (CABG) surgery involves diastolic cardiac arrest under cardiopulmonary bypass, while off-pump CABG (OPCABG) has become widespread in recent years. Methods: 174 patients who underwent OPCABG were included in the study. Patients were divided into two groups. Group I (n=90) received ivabradine and Group M (n=84) received metoprolol before surgery until postoperative day 10. Intraoperative arrhythmias and hypotension were recorded. Postoperative atrial fibrillation (AF) and arrhythmia, mortality and morbidity rates were assessed based on the 30-day postoperative follow-up. Results: There were no significant differences in the intraoperative amount of inotropic support and red blood cell transfusion between groups (P=0.87 and P=0.31). However, the rates of intraoperative arrhythmias and hypotension were not significantly higher in Group M (P=0.317 and P=0.47). Ventricular tachycardia/ventricular fibrillation (VT/VF) was observed in 2 patients in both groups. Postoperative AF occurred in 7 patients (7.7%) in Group I and in 10 patients (11.9%) in Group M. Although there was a trend towards a higher prevalence of AF in Group M patients, this did not reach statistical significance. In addition, mortality and morbidity rates were comparable between groups.