Combination hyperbaric oxygen and temozolomide therapy in c6 rat glioma model

DAGISTAN Y., Karaca I., BOZKURT E. R., OZAR E., YAGMURLU K., Toklu A., ...Daha Fazla

ACTA CIRURGICA BRASILEIRA, cilt.27, sa.6, ss.383-387, 2012 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 27 Sayı: 6
  • Basım Tarihi: 2012
  • Doi Numarası: 10.1590/s0102-86502012000600005
  • Dergi Adı: ACTA CIRURGICA BRASILEIRA
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.383-387
  • İstanbul Üniversitesi Adresli: Evet

Özet

PURPOSE: Temozolomide (TMZ) has anti-tumor activity in patients with malignant glioma. Hyperbaric oxygen (HBO) may enhance the efficacy of certain therapies that are limited because of the hypoxic tumor microenvironment. We examined the combined effects of TMZ-HBO in a rat glioma model.