Low dose daily rhGM-CSF application activates monocytes and dendritic cells in vivo

Demir G., Klein H., Tuzuner N.

LEUKEMIA RESEARCH, cilt.27, sa.12, ss.1105-1108, 2003 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 27 Konu: 12
  • Basım Tarihi: 2003
  • Doi Numarası: 10.1016/s0145-2126(03)00097-3
  • Sayfa Sayıları: ss.1105-1108


Granulocyte macrophage colony stimulating factor (GM-CSF) is a powerful cytokine with multiple actions. We investigated the effects of low dose daily rhGM-CSF application on monocytes and peripheral circulating dendritic cells (DC) in malignant melanoma patients in vivo. Twenty patients were included; rhGM-CSF was given as daily subcutaneous injections for 14 days. A significant increase was noted in monocytes and granulocytes, starting on the 5th day. Expression of CD95 (Apo-1/Fas) and CD45RO on monocytes increased significantly on the 5th day, and CD4 expression on monocytes increased significantly on the 14th day. Peripheral circulating dendritic cells which were 0.94% in the beginning, increased to 1.35% (P < 0.04) and to 1.96% (P < 0.001) on days 5 and 14, respectively. (C) 2003 Elsevier Science Ltd. All rights reserved.