Polymorphism of endothelial nitric oxide synthase gene in patients with erectile dysfunction

Erkan, E; Muslumanoglu, AY; Oktar, TAYFUN; Sanli, O; Ozbek, U; Kadioglu, A

doi:10.1111/j.1743-6109.2005.00165.x

Polymorphism of endothelial nitric oxide synthase gene in patients with erectile dysfunction

Erkan E., Muslumanoglu A., Oktar T. M., Sanli O., Ozbek U., Kadioglu A.

JOURNAL OF SEXUAL MEDICINE, cilt.3, sa.1, ss.69-75, 2006 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 3 Sayı: 1
Basım Tarihi: 2006
Doi Numarası: 10.1111/j.1743-6109.2005.00165.x
Dergi Adı: JOURNAL OF SEXUAL MEDICINE
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.69-75
İstanbul Üniversitesi Adresli: Evet

Özet

Introduction. Endothelial-derived nitric oxide (NO), which is produced by endothelial nitric oxide synthase (eNOS) in response to increased blood flow, maintains the tumescence phase of erection. The eNOS gene is located on the seventh somatic chromosome and the polymorphism of this gene has been reported to cause changes in the structure of enzyme system, resulting in disturbance of its activity.