Polymorphism of endothelial nitric oxide synthase gene in patients with erectile dysfunction

Erkan E., Muslumanoglu A., Oktar T. M., Sanli O., Ozbek U., Kadioglu A.

JOURNAL OF SEXUAL MEDICINE, cilt.3, sa.1, ss.69-75, 2006 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 3 Sayı: 1
  • Basım Tarihi: 2006
  • Doi Numarası: 10.1111/j.1743-6109.2005.00165.x
  • Dergi Adı: JOURNAL OF SEXUAL MEDICINE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.69-75
  • İstanbul Üniversitesi Adresli: Evet

Özet

Introduction. Endothelial-derived nitric oxide (NO), which is produced by endothelial nitric oxide synthase (eNOS) in response to increased blood flow, maintains the tumescence phase of erection. The eNOS gene is located on the seventh somatic chromosome and the polymorphism of this gene has been reported to cause changes in the structure of enzyme system, resulting in disturbance of its activity.