Polymorphism of endothelial nitric oxide synthase gene in patients with erectile dysfunction

Erkan E., Muslumanoglu A., Oktar T. M., Sanli O., Ozbek U., Kadioglu A.

JOURNAL OF SEXUAL MEDICINE, vol.3, no.1, pp.69-75, 2006 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 3 Issue: 1
  • Publication Date: 2006
  • Doi Number: 10.1111/j.1743-6109.2005.00165.x
  • Journal Name: JOURNAL OF SEXUAL MEDICINE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.69-75
  • Istanbul University Affiliated: Yes

Abstract

Introduction. Endothelial-derived nitric oxide (NO), which is produced by endothelial nitric oxide synthase (eNOS) in response to increased blood flow, maintains the tumescence phase of erection. The eNOS gene is located on the seventh somatic chromosome and the polymorphism of this gene has been reported to cause changes in the structure of enzyme system, resulting in disturbance of its activity.