Nickel oxide nanoparticles induced DNA damages in human liver cells

Abudayyak M. F., GÜZEL MEYDANLI E. E., Ozhan G.

ISTANBUL JOURNAL OF PHARMACY, vol.51, no.2, pp.175-182, 2021 (ESCI) identifier

  • Publication Type: Article / Article
  • Volume: 51 Issue: 2
  • Publication Date: 2021
  • Doi Number: 10.26650/istanbuljpharm.2021.837856
  • Journal Name: ISTANBUL JOURNAL OF PHARMACY
  • Journal Indexes: Emerging Sources Citation Index (ESCI)
  • Page Numbers: pp.175-182
  • Keywords: Nickel oxide, Nanoparticles, Genotoxicity, Oxidative stress, Apoptosis, ACUTE OXIDATIVE STRESS, IN-VITRO, INTRATRACHEAL INSTILLATION, COMET ASSAY, TOXICITY, NIO, CYTOTOXICITY, APOPTOSIS, NANOTOXICOLOGY, GENOTOXICITY
  • Istanbul University Affiliated: Yes

Abstract

Background and Aims: Nickel oxide nanoparticles (NiO-NPs) are one of the most used nanoparticles, especially as photosensitizers. Although some studies evaluate their toxicity in the liver, the information about their toxicity at the cellular and molecular levels is still controversial. In the present study, it was aimed to investigate the in vitro toxic potentials of NiO-NPs (average size 15.0 nm) in the liver (HepG2) cell Line.