Assessment of proarrhythmic ventricular electrophysiological remodeling in patients with rheumatoid arthritis

Aladag N., Guner A., Arslan C., Kalkan A. K., Kahraman S., Agus H. Z., ...Daha Fazla

HERZ, cilt.47, sa.5, ss.465-470, 2022 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 47 Sayı: 5
  • Basım Tarihi: 2022
  • Doi Numarası: 10.1007/s00059-021-05072-9
  • Dergi Adı: HERZ
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, EMBASE, MEDLINE
  • Sayfa Sayıları: ss.465-470
  • Anahtar Kelimeler: Rheumatoid arthritis, Electrocardiography, Ventricular repolarization, Proarrhythmic ventricular electrophysiological remodeling, Chronic inflammation, TP-E/QT RATIO, CORONARY-HEART-DISEASE, QT INTERVAL, CARDIOVASCULAR MORTALITY, ASSOCIATION, REPOLARIZATION, INFLAMMATION, DISPERSION, RISK, PEAK
  • İstanbul Üniversitesi Adresli: Hayır

Özet

Introduction Rheumatoid arthritis (RA) is related to cardiovascular disease and results in increased mortality rates. Ischemia, autonomic nervous system dysfunction, impaired cardiac ionic currents, and genetic predisposition may be the underlying mechanisms. Proarrhythmic ventricular electrophysiological remodeling detected on the basis of Tp-e interval, Tp-e/QT, and Tp-e/QTc ratios plays a key role in the prognosis. Our aim was to assess proarrhythmic ventricular electrophysiological remodeling in patients with RA, a well-known chronic inflammatory disorder. Materials and methods A total of 163 patients with RA and 47 patients as a control group were included in this retrospective study. Proarrhythmic ventricular electrophysiological remodeling markers were evaluated in both groups along with baseline demographic and clinical variables. Patients using medication or with chronic disorders that can affect ventricular repolarization markers were excluded. Results The patients with RA had prolonged Tp-e interval (66 ms [44-80]; 80 ms [78-96], p < 0.001) and increased Tp-e/QT ratio (0.18 [0.12-0.22]; 0.22 [0.20-0.24], p < 0.001) and Tp-e/QTc ratio (0.16 [0.11-0.19]; 0.20 [0.17-0.22], p < 0.001) compared to the control group. Conclusion The Tp-e interval and Tp-e/QT ratio, which may help to clarify the pathophysiological mechanisms of ventricular arrhythmias, were increased in patients with RA.