IL-22-secreting Th22 and IFN-gamma-secreting Th17 cells in Behcet's disease

Cetin E. A., Cosan F., ÇEFLE A., Deniz G.

MODERN RHEUMATOLOGY, cilt.24, sa.5, ss.802-807, 2014 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 24 Sayı: 5
  • Basım Tarihi: 2014
  • Doi Numarası: 10.3109/14397595.2013.879414
  • Dergi Adı: MODERN RHEUMATOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.802-807
  • Anahtar Kelimeler: Cytokines, Behcet's disease, IL-22, Th22 cells, Th17 cells, REGULATORY T-CELLS, GENOME-WIDE ASSOCIATION, PERIPHERAL-BLOOD, UVEITIS PATIENTS, EXPRESSION, PATHOGENESIS, INFLAMMATION, CYTOKINES, IL-22, DIFFERENTIATION
  • İstanbul Üniversitesi Adresli: Evet

Özet

Objective. Behcet's disease (BD) is a systemic inflammatory disease with unknown etiology. Studies have shown that some T helper (Th) 1-associated cytokines have role in the inflammation of BD. The CD4(+) Th cells can be differentiated into Th1, Th2, Th17 and Th22 secrete different cytokines to regulate immune system. In this study, cytokine secretion of Th subsets in BD was investigated.