Production of the novel fibrous structure of poly(epsilon-caprolactone)/tri-calcium phosphate/hexagonal boron nitride composites for bone tissue engineering


Ozbek B., Erdogan B., EKREN N., OKTAR F. N. , Akyol S. , Ben-Nissan B., ...More

JOURNAL OF THE AUSTRALIAN CERAMIC SOCIETY, vol.54, no.2, pp.251-260, 2018 (Peer-Reviewed Journal) identifier identifier

  • Publication Type: Article / Article
  • Volume: 54 Issue: 2
  • Publication Date: 2018
  • Doi Number: 10.1007/s41779-017-0149-0
  • Journal Name: JOURNAL OF THE AUSTRALIAN CERAMIC SOCIETY
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.251-260
  • Keywords: Biopolymers, Biofibers, Biomaterials, Poly(epsilon-caprolactone), Composites, POLYCAPROLACTONE, SCAFFOLDS, FABRICATION

Abstract

Nanofibrous composites of the poly(epsilon-caprolactone) (PCL), tricalcium phosphate (TCP), and hexagonal boron nitride (h-BN) with different compositions were manufactured by using an economical and non-complicated method called electrospinning. Produced fibrous structures showed no bead formation and had a clean surface. Characterization of the composites showed that particles were successfully mixed with polymer phase. High cell activity of SaOS-2 cells on the composites was observed with SEM images. In addition, fibrous scaffolds are biocompatible with human bone tissue and are highly degradable.