HLA-DR and -DQ Associations with Multiple Sclerosis in Turkey


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Eraksoy M. , Saruhan Direskeneli G. , Baykal B.

Human Immunology, vol.55, no.1, pp.59-65, 1997 (Journal Indexed in SCI Expanded)

  • Publication Type: Article / Article
  • Volume: 55 Issue: 1
  • Publication Date: 1997
  • Doi Number: 10.1016/s0198-8859(97)
  • Title of Journal : Human Immunology
  • Page Numbers: pp.59-65

Abstract

ABSTRACT: The DRB, DQA, and DQB subregions of

the major histocompatibility complex (MHC) were investigated

by polymerase chain reaction and sequence-specific

oligonucleotide probe hybridization (PCR/SSO) in

103 multiple sclerosis (MS) patients and 101 healthy

controls from Turkey. Significant differences were detected

between MS and control populations in the frequencies of

DRB1*1501 [29 vs. 14, p 5 0.02, odds ratio (OR) 5 2.4],

DRB1*04 (35 vs. 18, p 5 0.01, OR 5 2.3), DQB1*0302

(30 vs. 15, p 5 0.02, OR 5 2.3), DQB1*0602 (27 vs. 10,

p 5 0.005, OR 5 3.2), DQB1*0501 (10 vs. 24, p 5 0.01,

OR 5 0.3), DQA1*0101 (16 vs. 31, p 5 0.02, OR 5

0.4), and DQA1*0103 (7 vs. 19, p 5 0.02, OR 5 0.3).

These results confirm the proposed positive association of

the Dw2 (DRB1*1501 DQA1*0102 DQB1*0602) haplotype

with MS in Caucasians in our Turkish population

(25 vs. 8, p 5 0.003, OR 5 3.7). Furthermore, the

“putative” haplotype supposed to be more frequent in the

MS population of Mediterranean countries, namely

DRB1*04 DQA1*03 DQB1*0302, is also associated

with MS in Turkey (29 vs. 12, p 5 0.006, OR 5 2.9).

The presence of two different haplotypic associations in

MS emphasizes the complexity of the genetic susceptibility

to MS in different populations.