Use of CMAP, MScan fit-MUNE, and MUNIX in understanding neurodegeneration pattern of ALS and detection of early motor neuron loss in daily practice.

Gunes T., Sirin N. G., Sahin S., Kose E., Isak B.

Neuroscience letters, vol.741, pp.135488, 2021 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 741
  • Publication Date: 2021
  • Doi Number: 10.1016/j.neulet.2020.135488
  • Journal Name: Neuroscience letters
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Animal Behavior Abstracts, BIOSIS, CAB Abstracts, Chemical Abstracts Core, EMBASE, MEDLINE, Veterinary Science Database
  • Page Numbers: pp.135488
  • Keywords: Amyotrophic lateral sclerosis, motor unit number estimation, Denervation, Reinnervation, AMYOTROPHIC-LATERAL-SCLEROSIS, NUMBER INDEX MUNIX, REPRODUCIBILITY, UNITS, MUSCLES, DEGENERATION, ATROPHY
  • Istanbul University Affiliated: Yes


Background: The pattern of lower motor neuron (LMN) degeneration in amyotrophic lateral sclerosis (ALS), i.e., dying-back (from the nerve ending to cell body) or dying-forward (from the cell body to nerve ending), has been widely discussed. In this study, we aimed to evaluate LMN loss using compound muscle action potential (CMAP), motor unit number index (MUNIX), and MScan-fit-based motor unit number estimation (MUNE) to understand the pattern of neurodegeneration in ALS.