DNA damage effects of inhalation anesthetics in human bronchoalveolar cells

ÇUKUROVA Z., Cetingok H., Ozturk S., Gedikbasi A., HERGÜNSEL O., Ozturk D., ...Daha Fazla

MEDICINE, cilt.98, sa.32, 2019 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 98 Sayı: 32
  • Basım Tarihi: 2019
  • Doi Numarası: 10.1097/md.0000000000016518
  • Dergi Adı: MEDICINE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Anahtar Kelimeler: 8-hydroxy-2-deoxyguanosine, bronchoalveolar cells, comet assay, desflurane, DNA damage, inhalation anesthetics, sevoflurane, COMET ASSAY, IN-VIVO, HUMAN-LYMPHOCYTES, OXIDATIVE STRESS, DESFLURANE ANESTHESIA, SEVOFLURANE, GENOTOXICITY, ISOFLURANE, VITRO, HALOTHANE
  • İstanbul Üniversitesi Adresli: Evet

Özet

Background: The main objective was to evaluate and compare the local genotoxicity of sevoflurane and desflurane in bronchoalveolar cells, while the secondary outcome was to detect systemic oxidative DNA damage. To our knowledge, our study is the first one to evaluate the local effects of inhalation anesthetics in human bronchoalveolar cells in patients.