Effect of fresh human amniotic membrane on radiation-induced wounds in a murine experimental model


Diyarbakirlioglu M., Baghaki S. , Ercan A., Yazar S. K. , Gumusel A., CÖMERT M., ...Daha Fazla

EUROPEAN JOURNAL OF PLASTIC SURGERY, cilt.41, ss.279-284, 2018 (ESCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 41 Konu: 3
  • Basım Tarihi: 2018
  • Doi Numarası: 10.1007/s00238-017-1380-1
  • Dergi Adı: EUROPEAN JOURNAL OF PLASTIC SURGERY
  • Sayfa Sayıları: ss.279-284

Özet

Background Radiation-induced wounds are extremely difficult to treat. They may lead to severe infections and can even be life-threatening. Wound dressings, negative pressure wound treatment, hyperbaric oxygen therapy, and antibiotics are the main treatment modalities for radiation-induced wounds. Amniotic membrane is the innermost surface of the placenta. It has been shown that amniotic membrane induces re-epithelization, regulates angiogenesis, and decreases inflammation and fibrosis. Our proposed theory was that amniotic membrane can have a role in treating radiation-induced wounds by inducing epithelization and increasing wound tensile strength.