Impact of JAK2V617F Mutational Status on Phenotypic Features in Essential Thrombocythemia and Primary Myelofibrosis

Yonal I., Daglar-Aday A., Akadam-Teker B., Yilmaz C., Nalcaci M., Yavuz A., ...More

TURKISH JOURNAL OF HEMATOLOGY, vol.33, no.2, pp.94-101, 2016 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 33 Issue: 2
  • Publication Date: 2016
  • Doi Number: 10.4274/tjh.2014.0136
  • Journal Name: TURKISH JOURNAL OF HEMATOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.94-101
  • Keywords: JAK2V617F mutation, Essential thrombocythemia, Primary myelofibrosis, JAK2 V617F MUTATION, TYROSINE KINASE MUTATION, ALLELE BURDEN, POLYCYTHEMIA-VERA, MYELOID METAPLASIA, RISK, THROMBOSIS, DIAGNOSIS, LEUKEMIA, SUBTYPES
  • Istanbul University Affiliated: Yes

Abstract

Objective: The JAK2V617F mutation is present in the majority of patients with essential thrombocythemia (ET) and primary myelofibrosis (PMF). The impact of this mutation on disease phenotype in ET and PMF is still a matter of discussion. This study aims to determine whether there are differences in clinical presentation and disease outcome between ET and PMF patients with and without the JAK2V617F mutation.