Introduction: Lyme disease (LD), caused by the bacterium Borrelia burgdorferi, is mostly caused by bites of infected ticks. LD can affect multiple body systems or organs, and produce a broad range of symptoms. It typically involves the skin, nervous system, musculoskeletal system and the heart. A history of confirmed exposure to tick bites, in the patients who had typical signs and symptoms of Lyme borreliosis and positive antibody tests for B. burgdorferi antibodies are basis of the diagnosis. The treatment of LD is determined mainly by the clinical manifestations of the disease. Antibiotics may cure most cases of LD. The early and quick therapy may provide complete recovery. In this paper, seven patients with LD who had different clinical pictures are presented. The aim of this review was to summarize current knowledge of the symptoms, clinical diagnosis and treatment of Lyme borreliosis.