Synthesis of some new 6-methylimidazo[2,1-b]thiazole-5-carbohydrazide derivatives and their antimicrobial activities

Ur F., Cesur N., Birteksoz S., Otuk G.

ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH, cilt.54, sa.2, ss.125-129, 2004 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 54 Sayı: 2
  • Basım Tarihi: 2004
  • Dergi Adı: ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.125-129
  • İstanbul Üniversitesi Adresli: Evet

Özet

In this study, 14 new compounds having 6-methyl-N-2-(alkylidene/cycloalkylidene)imidazo[2,1-b]thiazole-5- carbohydrazide (3a-g), 3-[[(6-methylimidazo [2,1-b] thiazole-5-yl)carbonyl]amino]-4-thiazolidinone, (4a-d) and 4-[[(6methyl-imidazo[2,1-b]thiazole-5-yl)carbonyl]ami no]-1-thia-4-azaspiro[4.4]nonan/[4.5]decan-3-one (4e-g) structures were synthesized. The structures of the compounds were elucidated by UV, IR, H-1-NMR, C-13- NMR, H-1-C-13-COSY, mass spectra and elemental analysis. All compounds synthesized were tested for antimicrobial activity against Staphylococcus aureus ATCC 6538, Staphylococcus epidermidis ATCC 12228, Escherichia coli ATCC 8739, Klebsiella pneumoniae ATCC 4352, Pseudomonas aeruginosa ATCC 1539, Salmonella thypi, Shigella flexneri, Proteus mirabilis ATCC 14153, Candida albicans ATCC 10231 and Mycobacterium tuberculosis H(37)Rv. Only 4d and 4f demonstrated antimicrobial activity against S. epidermidis ATCC 12228 (MIC: 19.5 mug/ml and 39 mug/ml, respectively).