The association of HLA-B5 antigen with specific manifestations of Behçet's disease.

AZIZLERLI G., AKSUNGUR V., SARICA R., AKYOL E., OVUL C.

Dermatology (Basel, Switzerland), cilt.188, sa.4, ss.293-5, 1994 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 188 Sayı: 4
  • Basım Tarihi: 1994
  • Doi Numarası: 10.1159/000247169
  • Dergi Adı: Dermatology (Basel, Switzerland)
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.293-5
  • İstanbul Üniversitesi Adresli: Evet

Özet

The HLA-BS phenotype was investigated in 235 patients with Behcet's disease and in 100 healthy persons. HLA-BS was more frequent in the patients (77 vs. 30% p<0.001, relative risk=7.8). The frequency of HLA-BS was higher in patients with genital ulceration than without (82.3 vs. 63%, p<0.01). Patients with thrombophlebitis showed a less frequent positivity of HLA-BS antigen than the patients without thrombophlebitis (50 vs. 79.2%, p<0.02). These results suggest that HLA-BS-related genes not only affect the development of Behcet's disease but also the occurrence of its clinical manifestations.