The antihistamine fexofenadine does not affect I-Kr currents in a case report of drug-induced cardiac arrhythmia


Scherer C., Lerche C., Decher N., Dennis A., Maier P., Ficker E., ...More

BRITISH JOURNAL OF PHARMACOLOGY, vol.137, no.6, pp.892-900, 2002 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 137 Issue: 6
  • Publication Date: 2002
  • Doi Number: 10.1038/sj.bjp.0704873
  • Journal Name: BRITISH JOURNAL OF PHARMACOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.892-900
  • Istanbul University Affiliated: No

Abstract

1 The human HERG gene encodes the cardiac repolarizing K+ current I-Kr and is genetically inactivated in inherited long QT syndrome 2 (LQTS2). The antihistamine terfenadine blocks HERG channels, and can cause QT prolongation and torsades de pointes, whereas its carboxylate fexofenadine lacks HERG blocking activity.