The antihistamine fexofenadine does not affect I-Kr currents in a case report of drug-induced cardiac arrhythmia

Scherer, CR; Lerche, C; Decher, N; Dennis, AT; Maier, P; Ficker, E; Busch, AE; Wollnik, B; Steinmeyer, K

doi:10.1038/sj.bjp.0704873

The antihistamine fexofenadine does not affect I-Kr currents in a case report of drug-induced cardiac arrhythmia

Atıf İçin Kopyala

Scherer C., Lerche C., Decher N., Dennis A., Maier P., Ficker E., ...Daha Fazla

BRITISH JOURNAL OF PHARMACOLOGY, cilt.137, sa.6, ss.892-900, 2002 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 137 Sayı: 6
Basım Tarihi: 2002
Doi Numarası: 10.1038/sj.bjp.0704873
Dergi Adı: BRITISH JOURNAL OF PHARMACOLOGY
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.892-900
İstanbul Üniversitesi Adresli: Hayır

Özet

1 The human HERG gene encodes the cardiac repolarizing K+ current I-Kr and is genetically inactivated in inherited long QT syndrome 2 (LQTS2). The antihistamine terfenadine blocks HERG channels, and can cause QT prolongation and torsades de pointes, whereas its carboxylate fexofenadine lacks HERG blocking activity.