The antihistamine fexofenadine does not affect I-Kr currents in a case report of drug-induced cardiac arrhythmia


Scherer C., Lerche C., Decher N., Dennis A., Maier P., Ficker E., ...Daha Fazla

BRITISH JOURNAL OF PHARMACOLOGY, cilt.137, sa.6, ss.892-900, 2002 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 137 Konu: 6
  • Basım Tarihi: 2002
  • Doi Numarası: 10.1038/sj.bjp.0704873
  • Dergi Adı: BRITISH JOURNAL OF PHARMACOLOGY
  • Sayfa Sayıları: ss.892-900

Özet

1 The human HERG gene encodes the cardiac repolarizing K+ current I-Kr and is genetically inactivated in inherited long QT syndrome 2 (LQTS2). The antihistamine terfenadine blocks HERG channels, and can cause QT prolongation and torsades de pointes, whereas its carboxylate fexofenadine lacks HERG blocking activity.