Atıf İçin Kopyala
Scherer C., Lerche C., Decher N., Dennis A., Maier P., Ficker E., ...Daha Fazla
BRITISH JOURNAL OF PHARMACOLOGY, cilt.137, sa.6, ss.892-900, 2002 (SCI-Expanded)
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Yayın Türü:
Makale / Tam Makale
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Cilt numarası:
137
Sayı:
6
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Basım Tarihi:
2002
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Doi Numarası:
10.1038/sj.bjp.0704873
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Dergi Adı:
BRITISH JOURNAL OF PHARMACOLOGY
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Derginin Tarandığı İndeksler:
Science Citation Index Expanded (SCI-EXPANDED), Scopus
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Sayfa Sayıları:
ss.892-900
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İstanbul Üniversitesi Adresli:
Hayır
Özet
1 The human HERG gene encodes the cardiac repolarizing K+ current I-Kr and is genetically inactivated in inherited long QT syndrome 2 (LQTS2). The antihistamine terfenadine blocks HERG channels, and can cause QT prolongation and torsades de pointes, whereas its carboxylate fexofenadine lacks HERG blocking activity.