PHOTOINSTABILITY AND DEGRADATION KINETICS OF MEDAZEPAM


TOPALOGLU Y., YENER G.

PHARMAZIE, cilt.50, sa.2, ss.119-121, 1995 (SCI İndekslerine Giren Dergi) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 50 Konu: 2
  • Basım Tarihi: 1995
  • Dergi Adı: PHARMAZIE
  • Sayfa Sayıları: ss.119-121

Özet

As a consequence of irradiation of medazepam in an aprotic solution, 7-chloro-2,3-dihydro-1,5-epoxy-1-methyl-5-phenyl-1 H-1,4-benzodiazepine or 7-chloro-2,3-dihydro-1-methyl-5-phenyl-1 H-1,4-benzodiazepine 4-oxide was formed. It was observed that the degradation rate was rather high and a t(90) value of 3.16 h calculated.