PHOTOINSTABILITY AND DEGRADATION KINETICS OF MEDAZEPAM


TOPALOGLU Y., YENER G.

PHARMAZIE, vol.50, no.2, pp.119-121, 1995 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 50 Issue: 2
  • Publication Date: 1995
  • Journal Name: PHARMAZIE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.119-121
  • Istanbul University Affiliated: Yes

Abstract

As a consequence of irradiation of medazepam in an aprotic solution, 7-chloro-2,3-dihydro-1,5-epoxy-1-methyl-5-phenyl-1 H-1,4-benzodiazepine or 7-chloro-2,3-dihydro-1-methyl-5-phenyl-1 H-1,4-benzodiazepine 4-oxide was formed. It was observed that the degradation rate was rather high and a t(90) value of 3.16 h calculated.