Design, characterization and evaluation of the drug-loaded chitosan/cerium oxide nanoparticles with pH-controlled drug release

İLGAR M., KARAKUŞ S., Kilislioglu A.

POLYMER BULLETIN, vol.79, no.8, pp.6693-6708, 2022 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 79 Issue: 8
  • Publication Date: 2022
  • Doi Number: 10.1007/s00289-021-03839-y
  • Journal Name: POLYMER BULLETIN
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, PASCAL, Chemical Abstracts Core, Chimica, Compendex, INSPEC
  • Page Numbers: pp.6693-6708
  • Keywords: Cerium oxide nanoparticles, Chitosan, Drug release, Surface morphology, Inorganic nanocarriers, CEO2 NANOPARTICLES, SUSTAINED-RELEASE, DELIVERY, METHOTREXATE, CANCER, SYSTEM, GROWTH, CERIA
  • Istanbul University Affiliated: Yes


In recent years, polymer/metal oxide nanoparticles as a high-performance nanomaterials have gained great attention in different industrial areas such as biotechnology, cosmetic, automotive, textile, and concrete. In this study, novel chitosan/cerium oxide nanoparticles (Chi/CeO2 NPs) were synthesized to improve the bioavailability of the drug based on the assembly of inorganic nanoparticles at the polymer-NPs interfaces. The surface morphological property, chemical structure and drug release profile of synthesized NPs were characterized by scanning electron microscopy (SEM), Fourier transform infrared spectrophotometer (FTIR) X-ray diffractometer (XRD), and UV-visible technique. The particle size of spherical Chi/CeO2 NPs was found to be < 40 nm with a prepotent surface. Different kinetic model parameters such as zero-order, first-order, Higuchi, Bhaskar, and Ritger-Peppas models were calculated to investigate the drug release mechanism. The amount of Methotrexate (MTX) release from the surface of CeO2 NPs and the interface of Chi/CeO2 NPs were found to be 12.4% and 66.26%, respectively. According to experimental results, we observed that interfaces between Chi/CeO2 NPs and MTX in a structure could have a profound effect on the percentage of MTX drug release. We showed that the synthesized inorganic NPs could be proposed potentially as an effective inorganic nanocarrier with controlled MTX release.