Genetic polymorphisms in DNA repair gene APE1, XRCC1 and XPD and the risk of pre-eclampsia


Vural P. , Degirmencioglu S., Dogru-Abbasoglu S. , Saral N., Akgul C., Uysal M.

EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY, cilt.146, ss.160-164, 2009 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 146 Konu: 2
  • Basım Tarihi: 2009
  • Doi Numarası: 10.1016/j.ejogrb.2009.06.007
  • Dergi Adı: EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
  • Sayfa Sayıları: ss.160-164

Özet

Objective: Oxidative stress has been postulated as a major contributor to placental hypoperfusion and ischemia in pre-eclampsia (PE). Reactive oxygen species (ROS) generated during placental ischemia can cause oxidative damage to nucleic acids. Base excision repair (BER) and nucleotide excision repair (NER) are major pathways responsible for removing the oxidative DNA damage. Polymorphisms in DNA repair genes may be associated with differences in the repair efficiency of DNA damage.