Genetic polymorphisms in DNA repair gene APE1, XRCC1 and XPD and the risk of pre-eclampsia

Vural P., Degirmencioglu S., Dogru-Abbasoglu S., Saral N., Akgul C., Uysal M.

EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY, vol.146, no.2, pp.160-164, 2009 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 146 Issue: 2
  • Publication Date: 2009
  • Doi Number: 10.1016/j.ejogrb.2009.06.007
  • Journal Name: EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.160-164
  • Keywords: Preeclampsia, Polymorphism, DNA repair, APE1, XRCC1, XPD, BASE-EXCISION-REPAIR, SINGLE NUCLEOTIDE POLYMORPHISMS, ONSET ALZHEIMERS-DISEASE, BREAST-CANCER PATIENTS, FUNCTIONAL-CHARACTERIZATION, CELL CARCINOMA, DAMAGE REPAIR, LUNG-CANCER, ASSOCIATION, VARIANTS
  • Istanbul University Affiliated: Yes

Abstract

Objective: Oxidative stress has been postulated as a major contributor to placental hypoperfusion and ischemia in pre-eclampsia (PE). Reactive oxygen species (ROS) generated during placental ischemia can cause oxidative damage to nucleic acids. Base excision repair (BER) and nucleotide excision repair (NER) are major pathways responsible for removing the oxidative DNA damage. Polymorphisms in DNA repair genes may be associated with differences in the repair efficiency of DNA damage.