Electrochemical oxidation mechanism of eugenol on graphene modified carbon paste electrode and its analytical application to pharmaceutical analysis

Yıldız G., Aydogmus Z., Cinar M. E., Şenkal B. F., Öztürk T.

TALANTA, cilt.173, ss.1-8, 2017 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 173
  • Basım Tarihi: 2017
  • Doi Numarası: 10.1016/j.talanta.2017.05.056
  • Dergi Adı: TALANTA
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1-8
  • Anahtar Kelimeler: Eugenol, Electrochemical properties, Graphene modified carbon paste electrode, (CPE), Differential pulse voltammetry (DPV), DFT, PULSE VOLTAMMETRIC DETERMINATION, ANTIOXIDANT, NANOTUBES, ENERGIES, MODEL, QUANTIFICATION, SAMPLES
  • İstanbul Üniversitesi Adresli: Evet

Özet

Electrochemical properties of eugenol were investigated on a graphene modified carbon paste electrode (CPE) by using voltammetric methods, which exhibited a well-defined irreversible peak at about 0.7 V vs Ag/AgCl, NaCl (3 M) in Britton -Robinson buffer at pH 2.0. Mechanism of the electrochemical reaction of eugenol was studied by performing density functional theory (DFT) computations and mass spectroscopic analysis. (CPCM:water)-wB97XD/aug-cc-PVTZ//(CPCM:water)-wB97XD/6-31G(d) level calculations predicted that the formation of product P2, possessing a para-quinoid structure, is preferred rather than the product P1, suggested in the literature, having an ortho-quinoid system. Determination of eugenol in a pharmaceutical sample was realized in the light of the electrochemical findings, and a validated voltammetric method for quantitative analysis of eugenol in a pharmaceutical formulation was proposed. The differential pulse voltammogram (DPV) peak currents were found to be linear in the concentration range of 1.0 x 10(-7) to 1.7 x 10(-8) M. The limit of detection (LOD) and the limit of quantification (LOQ) were obtained to be 7.0 x 10(-9) and 2.3 x 10(-8), respectively.