COMT Val158Met polymorphism and executive functions in obsessive compulsive disorder

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Atıf İçin Kopyala

TÜKEL M. R., GÜRVİT İ. H., ASLANTAŞ ERTEKİN B., SARUHAN DİRESKENELİ G.

Journal of Neuropsychiatry and Clinical Neurosciences, cilt.25, sa.3, ss.214-221, 2013 (SCI-Expanded)

• Yayın Türü: Makale / Tam Makale
• Cilt numarası: 25 Sayı: 3
• Basım Tarihi: 2013
• Doi Numarası: 10.1176/appi.neuropsych.12040103
• Dergi Adı: Journal of Neuropsychiatry and Clinical Neurosciences
• Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Social Sciences Citation Index (SSCI), Scopus
• Sayfa Sayıları: ss.214-221
• İstanbul Üniversitesi Adresli: Evet

Özet

This study investigated the association between the catechol-O-methyl transferase (COMT) Val158Met polymorphism and executive functions in 101 patients with obsessive-compulsive disorder (OCD) and 100 healthy-control subjects (HS). Results showed that there was no significant difference for the genotype distributions between the OCD and HS groups. OCD-Met carrier subgroup's TMT B-A difference and lexical fluency scores were found to be significantly poorer than both HS subgroups. These findings suggest that lower activity of COMT associated with the Met allele, leading to higher levels of dopamine in the prefrontal cortex, lead to poorer executive function in OCD.