Transcriptional repressor Blimp1 regulates follicular regulatory T-cell homeostasis and function

Yang G., Yang X., Zhang J., Li G., Zheng D., Peng A., ...More

IMMUNOLOGY, vol.153, no.1, pp.105-117, 2018 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 153 Issue: 1
  • Publication Date: 2018
  • Doi Number: 10.1111/imm.12815
  • Journal Name: IMMUNOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.105-117
  • Keywords: autoinflammatory disease, neuroimmunology, neuroinflammation, regulatory T cells, T follicular helper cell, EXPERIMENTAL AUTOIMMUNE MYASTHENIA, GERMINAL CENTER REACTION, TREG CELLS, GRAVIS, ACTIVATION, EXPANSION, IMMUNITY, BALANCE, SUBSET, ROLES
  • Istanbul University Affiliated: Yes


The B-lymphocyte-induced maturation protein 1 (Blimp1) regulates T-cell homeostasis and function. Loss of Blimp1 could double the proportion of follicular regulatory T (Tfr) cells. However, the effects that Blimp1 may have on the function of Tfr cells remain unknown. Here we document the function for Blimp1 in Tfr cells invitro and invivo. Data presented in this study demonstrate that Tfr cells indirectly inhibit the activation and differentiation of B cells by negatively regulating follicular helper T cells, so lowering the secretion of antibody. Lack of Blimp1 makes the immune suppression function of Tfr cells impaired invitro. In the invivo study, adoptive transfer of Tfr cells could reduce immune responses in germinal centres and relieve the muscle weakness symptoms of mice with experimental autoimmune myasthenia gravis. Blimp1 deficiency resulted in reduced suppressive ability of Tfr cells. This study identifies that Tfr cells are potent suppressors of immunity and are controlled by Blimp1.