Research Information System
FUTURE VIROLOGY, vol.21, no.1, pp.25-27, 2026 (SCI-Expanded, Scopus)
We report the case of a 41-year-old male who was incidentally found to be hepatitis B surface antigen (HBsAg) positive during routine preoperative screening. Within 25 days, he developed malaise, jaundice, dark urine, pale stools, and right upper quadrant abdominal pain, with markedly elevated transaminases. Viral serology confirmed acute hepatitis B virus (HBV) infection, with high HBV deoxyribonucleic acid levels and positive hepatitis B e antigen. Imaging demonstrated acute acalculous cholecystitis, representing an extrahepatic manifestation of HBV. The patient was managed conservatively with hydration, analgesia, and close monitoring, without the need for antiviral therapy or surgical intervention. His symptoms gradually improved, and liver function tests normalized over two months. At follow-up, seroconversion was documented, with HBsAg clearance and development of protective antibodies by the fourth month, indicating complete viral resolution. He remained asymptomatic during six months of follow-up.