Topical drug delivery using chitosan nano- and microparticles

SEZER A. D., Cevher E.

EXPERT OPINION ON DRUG DELIVERY, vol.9, no.9, pp.1129-1146, 2012 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 9 Issue: 9
  • Publication Date: 2012
  • Doi Number: 10.1517/17425247.2012.702752
  • Journal Name: EXPERT OPINION ON DRUG DELIVERY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1129-1146
  • Keywords: biopolymer, chitosan, microparticle, nanoparticle, topical drug delivery, IN-VITRO CHARACTERIZATION, PRESSURE-GENE-GUN, TRIMETHYL CHITOSAN, NASAL DELIVERY, MUCOADHESIVE MICROSPHERES, MOLECULAR-WEIGHT, OCULAR DELIVERY, VIVO EVALUATION, LECITHIN/CHITOSAN NANOPARTICLES, ANTISENSE OLIGONUCLEOTIDE
  • Istanbul University Affiliated: Yes

Abstract

Introduction: Topical drug delivery offers important benefits for improving the therapeutic effect and reducing systemic side effects of the administered compounds. In addition, utilization of biopolymeric material-based systems can play a key role in developing new topical dosage forms and their applications. This review describes the advances that have been made, new strategies and as well as possible challenges of particular systems of chitosan used in topical drug delivery, including challenging innovations in topical usage of these systems that can make significant impact on clinical practice.