Cytokine levels in euthymic bipolar patients

GULOKSUZ S., Cetin E., CETIN T., Deniz G., Oral E. T., NUTT D. J.

JOURNAL OF AFFECTIVE DISORDERS, cilt.126, sa.3, ss.458-462, 2010 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 126 Sayı: 3
  • Basım Tarihi: 2010
  • Doi Numarası: 10.1016/j.jad.2010.04.027
  • Dergi Adı: JOURNAL OF AFFECTIVE DISORDERS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Social Sciences Citation Index (SSCI), Scopus
  • Sayfa Sayıları: ss.458-462
  • Anahtar Kelimeler: Bipolar disorder, Cytokines, Interleukin, Euthymic, Inflammation, Tumor necrosis factor, AFFECTIVE-DISORDER, LITHIUM, MANIA
  • İstanbul Üniversitesi Adresli: Evet

Özet

Background: The pathophysiology of bipolar disorder is not thoroughly understood. Several studies have investigated the possible role of cytokines in psychiatric disorders, based on their role in neuro-immune modulation; however, findings in studies on bipolar disorder remain limited and contradictory, and most studies have focused on either manic or depressive episodes. These studies suggest that both manic and depressive episodes could be pro-inflammatory states. The present study aimed to determine whether there are enduring differences in cytokine levels-unrelated to the effects of medication-between euthymic bipolar patients and healthy controls.