AA Amyloidosis: A Contemporary View


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Mirioglu S., Uludag O., Hurdogan O., KUMRU G., Berke I., Doumas S. A., ...Daha Fazla

Current Rheumatology Reports, cilt.26, sa.7, ss.248-259, 2024 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 26 Sayı: 7
  • Basım Tarihi: 2024
  • Doi Numarası: 10.1007/s11926-024-01147-8
  • Dergi Adı: Current Rheumatology Reports
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database
  • Sayfa Sayıları: ss.248-259
  • Anahtar Kelimeler: Amyloidosis, Arthritis, Autoinflammatory diseases, Chronic infection, Chronic inflammation, Serum amyloid A
  • İstanbul Üniversitesi Adresli: Evet

Özet

Purpose of Review: Amyloid A (AA) amyloidosis is an organ- or life-threatening complication of chronic inflammatory disorders. Here, we review the epidemiology, causes, pathogenesis, clinical features, and diagnostic and therapeutic strategies of AA amyloidosis. Recent Findings: The incidence of AA amyloidosis has declined due to better treatment of the underlying diseases. Histopathological examination is the gold standard of diagnosis, but magnetic resonance imaging can be used to detect cardiac involvement. There is yet no treatment option for the clearance of amyloid fibril deposits; therefore, the management strategy primarily aims to reduce serum amyloid A protein. Anti-inflammatory biologic agents have drastically expanded our therapeutic armamentarium. Kidney transplantation is preferred in patients with kidney failure, and the recurrence of amyloidosis in the allograft has become rare as transplant recipients have started to benefit from the new agents. Summary: The management of AA amyloidosis has been considerably changed over the recent years due to the novel therapeutic options aiming to control inflammatory activity. New agents capable of clearing amyloid deposits from the tissues are still needed.