Obsessive-compulsive disorder secondary to bilateral frontal damage due to a closed head injury


BİLGİÇ B. , Baral-Kulaksizoglu I., Hanagasi H., Saylan M., Aykutlu E., GÜRVİT İ. H. , ...More

Cognitive and Behavioral Neurology, vol.17, no.2, pp.118-120, 2004 (Journal Indexed in SCI Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 17 Issue: 2
  • Publication Date: 2004
  • Doi Number: 10.1097/01.wnn.0000117862.44205.ea
  • Title of Journal : Cognitive and Behavioral Neurology
  • Page Numbers: pp.118-120

Abstract

Objective: To describe a patient who exhibited obsessive-compulsive disorder and frontal lobe dysfunction signs after a closed head trauma. Background: Recent evidence indicates that frontal-subcortical circuits are involved in the pathogenesis of primary obsessive-compulsive disorder. There are a number of case reports of secondary obsessive-compulsive disorder after lesions involving certain parts of these circuits. Method: Clinical examinations, cognitive and behavioral assessments, and lesion analysis based on magnetic resonance imaging were conducted. Results: The patient displayed marked obsessive-compulsive behavior along with hyperorality and apathy. Magnetic resonance imaging showed symmetrical frontal-polar abnormal signal intensity. Topographic lesion analysis revealed involvement of Brodmann areas 11, 10, 24, 25, and 32. Conclusions: The patient presented in this report had both frontal lobe dysfunction signs and obsessive-compulsive disorder secondary to bilateral frontal damage due to a closed head injury. The etiological significance of head injury and frontal lobe involvement in obsessive-compulsive disorder is discussed in the context of the clinical and neuroimaging findings and of previous series of brain injured patients.