Antibacterial and Antibiofilm Activities of Ceragenins against Pseudomonas aeruginosa Clinical Isolates

Bozkurt Guzel, Çağla; Hacioglu, Mayram; Inci, Gozde; SAVAGE, Paul

doi:10.4274/tjps.galenos.2018.59023

Antibacterial and Antibiofilm Activities of Ceragenins against Pseudomonas aeruginosa Clinical Isolates

Atıf İçin Kopyala

Bozkurt Guzel C., Hacioglu M., Inci G., SAVAGE P. B.

TURKISH JOURNAL OF PHARMACEUTICAL SCIENCES, cilt.16, sa.4, ss.444-449, 2019 (ESCI)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 16 Sayı: 4
Basım Tarihi: 2019
Doi Numarası: 10.4274/tjps.galenos.2018.59023
Dergi Adı: TURKISH JOURNAL OF PHARMACEUTICAL SCIENCES
Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
Sayfa Sayıları: ss.444-449
İstanbul Üniversitesi Adresli: Evet

Özet

Objectives: Pseudomonas aeruginosa can cause life-threatening infections that are difficult to treat due to its high resistance to antibiotics and its ability to form antibiotic tolerant biofilms. Ceragenins, designed to mimic the activities of antimicrobial peptides, represent a promising new group of antibacterial agents that display potent anti-P. aeruginosa activity. The aim of this study was to evaluate the antibacterial and antibiofilm activities of ceragenins in comparison to colistin and ciprofloxacin against P. aeruginosa strains.