Antibacterial and Antibiofilm Activities of Ceragenins against Pseudomonas aeruginosa Clinical Isolates


Bozkurt Guzel C. , Hacioglu M. , Inci G., SAVAGE P. B.

TURKISH JOURNAL OF PHARMACEUTICAL SCIENCES, cilt.16, ss.444-449, 2019 (ESCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 16 Konu: 4
  • Basım Tarihi: 2019
  • Doi Numarası: 10.4274/tjps.galenos.2018.59023
  • Dergi Adı: TURKISH JOURNAL OF PHARMACEUTICAL SCIENCES
  • Sayfa Sayıları: ss.444-449

Özet

Objectives: Pseudomonas aeruginosa can cause life-threatening infections that are difficult to treat due to its high resistance to antibiotics and its ability to form antibiotic tolerant biofilms. Ceragenins, designed to mimic the activities of antimicrobial peptides, represent a promising new group of antibacterial agents that display potent anti-P. aeruginosa activity. The aim of this study was to evaluate the antibacterial and antibiofilm activities of ceragenins in comparison to colistin and ciprofloxacin against P. aeruginosa strains.