Akademik Veri Yönetim Sistemi
Comprehensive medicine, cilt.15, sa.1, ss.27-34, 2023 (Hakemli Dergi)
Objective: Many risk factors have been associated with breast cancer (BC) in years. The objective of our study was to predict possible risk factors related to BC and to contribute national and global screening programs. Materials and Methods: A case–control study was created among women who were examined at the department of Surgery, Oncology Institute, Istanbul University, between January 2009 and December 2015. The patients were divided into two groups as 1006 women with BC diagnosis and and 3439 women witout BC. A database was formed by questioning demographics, clinical characteristics of patients, and the possible factors that could be associated with BC were analyzed. Results: According to the results of the study, high education level and being postmenopausal were found to be closely related to BC (p<0.0001). In addition, as having history of smoking (Odds Ratio [OR] 2.3; 95% confidence interval [CI]: 1.2–4.7, p=0.02), as having first-degree relative with BC (OR 2.4; 95% CI: 1.1–5.3, p=0.03), as having a member in family with BC under the age of 50 (OR 3.1; 95% CI 1.9–8.1, p=0.005), as being high body mass indexed-patient (OR 1.2; 95% CI: 1.1–1.3, p=0.001), such as not giving birth (OR 2.1; 95% CI: 1.2–4.6, p=0.01), and used postmenopausal hormone replacement therapy (OR 2.88; 95% CI: 0.02–2.4, p=0.049) were identified as important risk factors associated with BC. Conclusion: This present study has determined national-based significant risk factors associated with BC. We can surely extrapolate that this study is one of the important briefs to support national and also worldwide risk models and screening programs.