Association between polymorphisms of DNA repair genes and risk of type 2 diabetes mellitus in the Turkish population

Tokmak, Neslihan; Yilmaz, Umit; Yilmaz, Nesibe; Yurdum, Leman; Yigitbasi, Nihal; Ergen, HAYRİYE; Karaali, Zeynep; Zeybek, ŞAKİR

doi:10.1515/tjb-2016-0107

Association between polymorphisms of DNA repair genes and risk of type 2 diabetes mellitus in the Turkish population

Tokmak N., Yilmaz U., Yilmaz N., Yurdum L. M., Yigitbasi N., Ergen H. A., ...More

TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI, vol.43, no.2, pp.167-172, 2018 (SCI-Expanded, Scopus, TRDizin)

Publication Type: Article / Article
Volume: 43 Issue: 2
Publication Date: 2018
Doi Number: 10.1515/tjb-2016-0107
Journal Name: TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
Page Numbers: pp.167-172
Istanbul University Affiliated: Yes

Abstract

Objectives: DNA repair mechanisms work insufficiently in T2DM patients and hyperglycemia seen in diabetes disturbs the oxidant-antioxidant balance thus cause oxidative damage on DNA. The effects of the DNA repair genes' have not yet been investigated on diabetes. The aim of this study was to investigate the association between APE1 Asp148Glu and XPG Asp1104His polymorphisms with T2DM in the Turkish population.